Accepted
at 12:12 a.m. Feb, 23, 2024
by
Michael_B
Author:
Parker
Type of change:
Updated content
Rationale for change
Added the -1.
ATP and citrate are inhibitors of PFK1.
"In general, PFK-1 is sensitive to the energy level of the cell, as indicated by the abundance of ATP, and is regulated by a number of effectors including ATP, adenosine monophosphate (AMP), F-6-P, F-1,6-P2, and citrate." PMID: 30918224
The other isoform, PFK2, is not inhibited by ATP.
"However, unlike PFK-1, PFK-2 is not affected by ATP concentrations." PMID: 24280138
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