Accepted at 3:50 p.m. Feb, 08, 2024 by Michael_B
Author: Parker
Co-authors: Ahmed7
Related Note: 1555816032943
Rationale for change

Some grammatical changes.
The last sentance stated binding 2,3 BPG causes HG to be "useless". This is a lofty clame and not correct. It lowers the affinity for oxygen on that HG, causing more offloading of oxygen to target tissues at a macro level. As the HG, with a lowered affinity, binds oxygen when returning to the lungs, the partial pressure of oxygen being high, oxygen will be able to bind to HG, causing a conformational change that forces the 2,3 BPG out of the inner HG pocket, raising the affinity of HG to oxygen. Further allowing oxygen to bind oxygen to all 4 subunits.

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#AK_MCAT_v2::#AAMC::Concepts::B/B::Foundational_Concept_03::3B-Structure_and_Function_of_Organ_Systems #AK_MCAT_v2::#AAMC::Concepts::B/B::Foundational_Concept_01::1D-Bioenergetics_and_Fuel_Metabolism #AK_Other::!AK_UpdateTags::!AK_UpdateTags::^temporary::ImageFix_MCAT::08::done #AK_MCAT_v2::#KhanAcademy::Biology::Organ-Systems::Cardiovascular_System #AK_MCAT_v2::#AK_Other::!AK_UpdateTags::AnKing_Image::Aiman #AK_MCAT_v2::AK_Original_Decks::MileDown::Biology::Cardiovascular_System #AK_MCAT_v2::$Errata::Text_Edited #AK_MCAT_v2::#UWorld_Books::Biology::Ch-13-Circulatory_System #AK_MCAT_v2::#Kaplan::Biology::Ch-07-The-Cardiovascular-System #AK_MCAT_v2::#UWorld::400400 AnkiHub_Subdeck::AnKing-MCAT::Biology