Rejected at 12:30 a.m. Nov, 01, 2023 ] by dollajas
Author: Fikthenig
Related Note: 1473995572360
Rationale for change

This isn't totally right because subendothelial collagen is what primarily activates the extrinsic pathway or tissue factor(factor 3) which then activates factor 7 as stated by bootcamp. The negative charges found on platelets(polyanion surface) is what largely activates factor 12 of the intrinsic pathway.
Aside from Bootcamp, other links that prove this are:

"Factor XII has the unique property to autoactivate on negatively charged surfaces." (Alvin H. Schmaier, in xPharm: The Comprehensive Pharmacology Reference, 2007)

"Factor XII (FXII) is a protease that is mainly produced in the liver and circulates in plasma as a single chain zymogen. Following contact with negatively charged surfaces, FXII is converted into the two-chain active form, FXIIa." (https://pubmed.ncbi.nlm.nih.gov/30118759/)

Rejection reason

This change isn’t testable, if you find any supporting data from Amboss, uworld, or fa2023 I can reconsider

Text Text
Extra
Lecture Notes
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Missed Questions
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Pathoma
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Boards and Beyond
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First Aid


Sketchy

Sketchy Physiology: Hematology


Sketchy 2






Watch Bleeding Disorders: Coagulation Factor Disorders DDx
Sketchy Extra
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Picmonic
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Pixorize


Review Intrinsic Pathway of Coagulation
Physeo
Bootcamp
Watch associated Bootcamp video - Coagulation Cascade
OME

Additional Resources
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One by one
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Changed Tags
#AK_Step1_v12::#Bootcamp::Hematology_and_Oncology::Coagulation_and_Fibrinolysis::Coagulation_Cascade #AK_Step1_v12::#Bootcamp::Hematology_and_Oncology::07_Coagulation_and_Fibrinolysis::01_Coagulation_Cascade
#AK_Step1_v12::#SketchyPhysiology::10_Hematology::01_Blood_Components_&_Function::01_Coagulation_Cascade #AK_Step1_v12::^Systems::HemeOnc::Hematology !AK_UpdateTags::Step1decks::Zanki-Step-Decks::Zanki-Hematology-&-Oncology::Pathoma-Hematology #AK_Step1_v12::#Physeo::11_Pathology::10_HemeOnc_Pathology::02_Secondary_Hemostasis #AK_Step1_v12::#OME::Clinical::Internal_Medicine::Hematology-Oncology::Approach_To_Bleeding #AK_Step1_v12::#Pathoma::04_Hemostasis::02_Secondary_Hemostasis_&_Related_Disorders #AK_Step2_v12::#SketchyIM::08_Hematology_&_Oncology::02_Bleeding_&_Clotting_Disorders::02_Bleeding_Disorders_2_Coagulation_Factor_Disorders_Ddx #AK_Original_Decks::Step_1::Zanki_Step_Decks::Zanki_Hematology_&_Oncology::Pathoma_Hematology #AK_Step1_v12::#FirstAid::10_Hematology_Oncology::03_Physiology::05_Coagulation_&_Kinin_Pathways #AK_Step1_v12::#FirstAid::10_Hematology_Oncology::03_Physiology::05_Coagulation_&_Kinin_Pathways::Coagulation_Cascade #AK_Step2_v12::#B&B::07_Hematology_&_Oncology::02_Coagulation::02_Coagulopathy #AK_Step1_v12::#Physeo::^physeo_image_update !AK_UpdateTags::AnKing_Image::Aiman #AK_Step1_v12::#FirstAid::10_Hematology_Oncology::04_Pathology::16_Coagulation_Disorders::*Coagulation_Cascade #AK_Step1_v12::^Other::^HighYield::1-HighYield #AK_Step1_v12::#B&B::11_Hematology::01_Hemostasis::01_Coagulation #AK_Step1_v12::#Pixorize::01_Biochemistry::17_Coagulation::03_Intrinsic_Pathway_of_Coagulation